Classical psychedelics have yet to be approved for the treatment of any illness and in most countries are presently illegal (designated as most dangerous substances by international organizations). However, preliminary scientific research data and plenty of anecdotal evidence suggest that psychedelic-assisted therapies may be extremely effective for some of our most prevalent, debilitating, and fatal psychological or neurological conditions.
Classical psychedelics are considered to be relatively safe drugs when used recreationally. The risks are likely to be higher if the user is on his own, takes the wrong dose, is in the wrong place, bad time, or is already under the influence of other substances – usually and probably most dangerously, alcohol. According to a Global Drug Survey, Psilocybe mushrooms are the safest of all the drugs people take recreationally.
Contraindications and dosage
Many people who want to try magic mushrooms are still on medication and want to know if it’s possible to mix their medication with psychedelics. While psilocybin has been shown to effectively treat depression and a variety of other mental health conditions, some antidepressant drugs can interact with the substance in a dangerous or undesirable way.
Antidepressant drugs may block the therapeutic effects of Psilocybin. If you are on antidepressants, you need to ask your health provider to help you stop taking them before considering psychedelics. SSRIs function by preventing excess serotonin from being cleared from the brain, resulting in a temporary increase in serotonin levels. Although it has been hypothesized that this may contribute to serotonin syndrome in extreme situations, such risks can be reduced with appropriate guidance and medical supervision. Most common SSRIs are:
- Citalopram (Celexa, Cipramil)
- Escitalopram (Lexapro, Cipralex)
- Fluoxetine (Prozac, Sarafem)
- Fluvoxamine (Luvox, Faverin)
- Paroxetine (Paxil, Seroxat)
- Sertraline (Zoloft, Lustral)
Health conditions that psilocybin may worsen
At first, the findings revealed that people who had used psychedelic drugs were more likely to have mental health issues. However, the researchers took into account a variety of variables that may have influenced the findings, including the participants’ age, gender, and their experience with any highly stressful life event, all of which may influence the likelihood of mental health problems. When those factors were taken into account, the researchers found that people who had used psychedelics were no more likely to develop mental health problems than those who hadn’t used the drugs.
However, it’s not advisable to use psychedelics if you or your family members had psychotic symptoms.
Mushrooms in non-clinical settings are typically eaten orally, either as dried caps and stems or steeped in hot water and drunk as a tea, with a typical dose of 1-2.5 grams, though potency varies depending on the volume. Fresh mushrooms are usually less active than dried mushrooms. There is virtually no chance of accidental deadly overdose with psilocybin mushrooms.
Johns Hopkins study found Psilocybin dosage sweet spot for positive and lasting effects
Researchers found that as higher doses of chemically pure psilocybin were administered, the recorded positive effects increased, but there was also a sharp rise in the negative effects at the very highest dose, which was perhaps unsurprising. At the maximum dose (30 mg/70 kg, p.o. – meaning “per oral” or “by mouth”), 78 percent of the volunteers recorded one of the top five most spiritually important events of their lives, but those experiencing anxiety, stress, and fear episodes increased sixfold, resulting in about a third of those in the study showing signs of psychological distress.
By contrast, only one of the volunteers receiving the second-highest dose (20mg/70 kg, p.o.) reported having negative issues, and all benefited from positive experiences, although with less intensity than at the highest dose. Critically, even the lowest amount used in the study resulted in notable and long-lasting positive changes in the attitudes, behavior, overall satisfaction and spiritual beliefs of the subjects during the period of study. These changes were also noticed by family members and friends.
The concentrations of psilocin and psilocybin, as determined by high-performance liquid chromatography, are in the range of 0.14–0.42% and 0.37–1.30% (dry weight) in the whole mushroom, 0.17–0.78%, and 0.44–1.35% in the cap, and 0.09 and 0.30%/0.05–1.27% in the stem, respectively.
Buying psychedelics online
Purchasing drugs over the internet, via social media, or on the dark web can be highly dangerous and lead to death. The potency of drugs varies from one batch to the next. Even within the same batch, the intensity of the tablets may differ. There are no quality and purity control or safety tests on illicit products. It’s possible that the drug you think you’re buying is just a minor component of the overall product or isn’t present at all. To bulk up illegal drugs and maximize the amount of money the seller gets, they are often mixed with other substances. You can’t say if a drug would have the effect you predict, have no effect at all, or have more harmful side effects than you expected.
Buying illicit drugs or psychoactive substances is the riskiest choice. If you buy drugs online, test them first. When consuming it, start with a small dose and gradually increase the dosage, giving it enough time to achieve its full effect. Be mindful that the full effect of certain medications can take a few hours or longer to manifest. A slow response does not always imply that the medication is ineffective. Do not use drugs alone; make sure someone is nearby and knows how to assist you if you have a negative reaction or overdose.
Only a small portion of the internet is indexed by Google. According to some figures, there is 500 times more content on the internet than Google returns in search results. The “surface web” refers to the links that Google and other search engines return when you type in a query, while the “deep web” or “invisible web” refers to all other, non-searchable content.
Drug users value the convenience and pace of buying drugs through apps like Snapchat, according to a study from Royal Holloway, University of London. It warns that buyers’ personal safety and drug quality are at risk and that many feel falsely secure of avoiding law enforcement. It is “crucial and urgent” to inform young people about the threats, according to the report. “On the whole, app consumers had well-rehearsed narratives that explained their continued confidence in buying substances from unknown suppliers on apps,” according to the report.
The study poses some questions about the safety of people who buy drugs across these channels. It also mentions that many people believe that buying drugs this way would allow them to escape law enforcement. “The main point is that many app users are misinformed about the security they have, or make incorrect assumptions about them.” “It is also important to provide education about the security risks of using apps.”
Drug testing: spot – color tests
Quality control in the illicit drug market is not sufficient. Often the street seller doesn’t know the drug content of the goods they offer so what chance the buyer or the drug service? Impure street drugs can be dangerous. There are some urban legends about street drugs. The primary reason for this is that sometimes these substances are laced with poisons like rat poison, strychnine, and brick dust. In reality, contamination of this kind is uncommon, but there are real dangers in the producer’s effort to make the drugs cheaper, by mixing them with other, more potent, and possibly more dangerous psychoactive substances.
One of the cheapest and most popular methods for testing drugs is the spot/color tests, which are based on chemical reactions between analytes and indicators. Cobalt thiocyanate, Dille-Koppanyi, Duquenois-Levine, Mandelin, Marquis, nitric acid, para-dimethylaminobenzaldehyde, ferric chloride, Froehde, Mecke, Zwikker, and Simon’s (nitroprusside) are some of the potential indicator measures. The indicator interacts chemically with the analyte, causing a reaction that results in a specific color staining, which varies depending on the analyte examined. The spots are then visually compared to reference charts, with the Munsell color charts serving as the existing norm.
Psilocybe mushrooms come in a range of shapes and sizes, with some of them looking the same. Some lookalikes are highly poisonous, and ingesting them can result in serious consequences, including death. As a result, distinguishing between the various types of mushrooms is important, especially for those who prefer a high dose of shrooms. Here are a few key indicators to help you distinguish the psilocybin mushrooms.
Some of the characteristics of psilocybin mushrooms are similar. Observers should look for mushrooms that are golden brown in color, but this is not always the case. Their stems sometimes have a blue mottling, particularly when bruised—interestingly, this is caused by a chemical reaction that occurs when psilocybin and oxygen come into contact. Finally, psilocybin mushrooms have a purple veil that covers the gills, or a thin dark purple ring on the stem if it is broken.
Find a mycologist in your area and ask if you can accompany them on one of their outings. Most of the folks in mycology are really friendly. Never ingest anything that you’re uncertain of…and even then, get a second and third and fourth opinion. Better safe than sorry!