More than 40 hallucinogenic mushroom fruiting bodies (or amounts containing more than 50 mg of psilocin or the corresponding quantity of psilocybin, approximately 70 mg) are considered “greater than small amount” in the Czech Republic.
Many people who want to try magic mushrooms are still on medication and want to know if it’s possible to mix their medication with psychedelics. While psilocybin has been shown to effectively treat depression and a variety of other mental health conditions, some antidepressant drugs can interact with the substance in a dangerous or undesirable way.
Antidepressant drugs may block the therapeutic effects of Psilocybin. If you are on antidepressants, you need to ask your health provider to help you stop taking them before considering psychedelics. SSRIs function by preventing excess serotonin from being cleared from the brain, resulting in a temporary increase in serotonin levels. Although it has been hypothesized that this may contribute to serotonin syndrome in extreme situations, such risks can be reduced with appropriate guidance and medical supervision. Most common SSRIs are:
- Citalopram (Celexa, Cipramil)
- Escitalopram (Lexapro, Cipralex)
- Fluoxetine (Prozac, Sarafem)
- Fluvoxamine (Luvox, Faverin)
- Paroxetine (Paxil, Seroxat)
- Sertraline (Zoloft, Lustral)
Health conditions that psilocybin may worsen
At first, the findings revealed that people who had used psychedelic drugs were more likely to have mental health issues. However, the researchers took into account a variety of variables that may have influenced the findings, including the participants’ age, gender, and their experience with any highly stressful life event, all of which may influence the likelihood of mental health problems. When those factors were taken into account, the researchers found that people who had used psychedelics were no more likely to develop mental health problems than those who hadn’t used the drugs.
However, it’s not advisable to use psychedelics if you or your family members had psychotic symptoms.
Johns Hopkins study found Psilocybin dosage sweet spot for positive and lasting effects
Researchers found that as higher doses of chemically pure psilocybin were administered, the recorded positive effects increased, but there was also a sharp rise in the negative effects at the very highest dose, which was perhaps unsurprising. At the maximum dose (30 mg/70 kg, p.o. – meaning “per oral” or “by mouth”), 78 percent of the volunteers recorded one of the top five most spiritually important events of their lives, but those experiencing anxiety, stress, and fear episodes increased sixfold, resulting in about a third of those in the study showing signs of psychological distress.
By contrast, only one of the volunteers receiving the second-highest dose (20mg/70 kg, p.o.) reported having negative issues, and all benefited from positive experiences, although with less intensity than at the highest dose. Critically, even the lowest amount used in the study resulted in notable and long-lasting positive changes in the attitudes, behavior, overall satisfaction and spiritual beliefs of the subjects during the period of study. These changes were also noticed by family members and friends.
The concentrations of psilocin and psilocybin, as determined by high-performance liquid chromatography, are in the range of 0.14–0.42% and 0.37–1.30% (dry weight) in the whole mushroom, 0.17–0.78%, and 0.44–1.35% in the cap, and 0.09 and 0.30%/0.05–1.27% in the stem, respectively.
Psychedelics-assisted psychotherapy in the Czech Republic
One of the biggest challenges, according to Tomáš Pálenícek, head of psychedelic research at the Czech National Institute of Mental Health, is the current classification of psychedelics as drugs of no therapeutic value. As a result, it would be wise to take the appropriate measures to reclassify these drugs into a different schedule. However, Ketamine therapy is legal in the Czech Republic, and there are clinics that openly help to integrate the psychedelic experience. Thanks to the legacy of Stanislav Groff, the country has some professionals that can help to integrate the psychedelic experience, but psychedelics themselves are not legal yet.